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Conference
"HPV-16, 18, 31, 45 Viral Loads in Anal Intraepithelial Lesions in HIV-seropositive Men" Dr. Alexandra de Pokomandy (biography) English - 2006-05-27 - 20 minutes
(21 slides)
Summary : The Human Immunodeficiency and PapillomaVirus Research Group (HIPVIRG) is an ongoing prospective study following HIV infected men in the Montreal area. The objective is to examine the evolution of HPV induced anal intraepithelial neoplasia (AIN). This study gathered data on lifestyle, viral loads, CD4+ counts, anal cytology, HPV testing and anal biopsies. A cross-sectional study from this cohort was conducted by De Pokomandy and colleagues to explore the association of HPV 16, 18, 31, and 45 viral loads and the grade of AIN. This association was computed using multivariate logistic regression. Outcome was defined as high grade (AIN = 2 or 3) versus low grade (AIN = normal or 1) as identified by anal biopsies and the exposure to viral loads for the four HPV subtypes were measured by real-time PCR. Covariates of age, CD4+ count and smoking were adjusted for. Dr. De Pokomandy presents her findings on the level of HPV viral load as AIN lesion grade increases. Moreover, she discusses other potential risk factors for low grade versus high grade AIN.
Learning objectives : After viewing this presentation, participants will be able to discuss:
- An overview of HIV and HPV (human papillomavirus) infection and anal intraepithelial neoplasia (AIN);
- The HIPVIRG cohort study;
- The association of HPV viral loads and the grade of AIN in HIV seropositive men.
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