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Conference
"Sequencing Antiretroviral Therapy: What are the Data?" Dr. Sharon Walmsley (biography) English - 2002-04-26 - 60 minutes
Learning objectives : Part 1: sequencing for resistance
To examine the reasons why sequencing antiretroviral therapy is necessary.
Factors in selecting one HAART therapy among many comparable ones.
Discussion of different kinds of mutations, eg NAMS, TAMS, M184V, cross-class etc.
Possible sequencing strategies.
Trizivir therapy.
Part 2: sequencing for simplification
Simplification involves lower drug dosing frequency, pill burden, food/ fasting requirements.
Sequencing for toxicity: switch an agent in the same/other class with no toxicity. Mitochondrial toxicity (inhibition of mitochondrial DNA polymerase).
Discussion of the risk of hyperlactemia. Study results of lactic acidosis.
Studies of the risk of lipodystrophy associated with various drugs.
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